Consultancy |
Discussions on sample collection, experimental design, recommended controls, platform suitability and biochemical coverage |
1 - 2 weeks |
Free |
|
Not applicable |
Blood sample preparation and storage for metabolomics |
Automation of the process of blood sampling and storage in order to reduce the need for manual work and monotonous activities and the risk of errors |
Several months |
|
Automatic blood collection and transport machines |
Not applicable |
Quantitative Lipidomics for >1000 lipid species |
Flow injection based analysis using the Lipidyzer platform |
Custom* |
€60 - €200 |
Lipidyzer platform |
Lipidyzer software (integrated) |
Bile Acid analysis |
LC-MS/MS analysis of >10 bile acids in different matrices |
Custom* |
€50 - €100 |
UHPLC-Qtrap 6500 |
Multiquant |
Oxylipids |
90 oxylipids in one panel, different matrices |
Custom* |
€50 - €100 |
UHPLC-Qtrap 6500 |
Multiquant |
Lipoprotein analysis |
Quantification of >175 lipoprotein parameters using the Bruker IVDr platfrom |
Custom* |
€40 - €100 |
NMR |
Bruker IVDr |
Amino Acids |
Quantitative analysis of amino acid metabolism |
Custom* |
€40 - €100 |
NMR |
TopSpin |
Central Energy Metabolism |
Quantitative analysis of TCA cycel, PPP etc. |
Custom* |
€40 - €100 |
NMR |
TopSpin |
Exploratory Metabolomics |
Untargeted Metabolomics |
Custom* |
€50 - €100 |
UHPLC-TT6600 |
MS-DIAL |
Exploratory Lipidomics |
Untargeted Lipidomics |
Custom* |
€40 - €100 |
UHPLC-TT6600 |
MS-DIAL |
Short Chain Fatty Acids |
SCFA such as acetic, propionic and butyric acid in different matrices |
Custom* |
€40 - €100 |
GC/MS |
Excel |
Fatty acids |
Total FA analysis C2-C24 |
Custom* |
€50 - €100 |
GC/MS |
Excel |
Sterols |
Distal cholesterol biosynthesis analysis |
Custom* |
€50 - €100 |
GC/MS |
Excel |
Signaling lipid & lipid mediator profiling |
Targeted analysis focusing on inflammation, oxidative stress, immune response, incl. a.o. oxylipins, endocannabinoids, bile acids (>200 targets) |
2 months |
€50 - 100 / sample depending on sample type and study size** |
Nominal mass resolution UPLC-MS/MS |
In-house pipeline |
Global RP deep metabolic profiling |
Broad coverage of medium polar metabolites including gut metabolites |
2 months |
€50 - 100 / sample depending on sample type and study size** |
UPLC-HRMS |
In-house pipeline |
Global HILIC deep metabolic profiling |
Broad coverage of polar metabolites including central carbon and energy metabolism |
2 months |
€50 - 100 / sample depending on sample type and study size** |
UPLC-HRMS |
In-house pipeline |
Lipidomics |
Targeted lipid profiling of over 1000 species in 22 lipid classes |
2 months |
€50 - 100 / sample depending on sample type and study size** |
Nominal mass resolution UPLC-MS/MS |
In-house pipeline |
Custom targeted panels |
Targeted analysis with a focus on specific pathways or chemical classes. Examples are biogenic amines, bile acids, acylcarnitines, tryptophan pathway, isotope tracer analysis |
Custom* |
Custom** |
Custom |
In-house pipeline |
Miniaturized metabolomics analysis |
Adapted sample prep of above platforms for sample limited applications such as organoids, organ-on-a-chip, moving towards single cell analysis |
Custom* |
Custom** |
Custom |
In-house pipeline |
Untargeted metabolomics for heparin plasma or CSF |
IEM panel, WES-based analysis, untargeted analysis with/without interpretation |
To be agreed upon, for research
± 4 - 6 months |
€390-1100 |
Agilent 6545 QTOF |
In-house pipeline |