Manuscript submission for a special issue of Genes-MDPI

X-omics consortium member Mohsen Ghanbari will be the guest editor of a special issue of Genes-MDPI, an Open Access journal of genetics and genomics.

This special edition will present the latest research findings and developments in the field of cardiovascular metabolism.

Findings from metabolomics studies have contributed to a better understanding of the metabolic changes that occur in cardiovascular diseases, and have identified new disease biomarkers. The integration of genetics, metabolomics, and other omics platforms in a systems biology approach holds potential for elucidating novel genetic markers and mechanisms for cardiovascular disease.

We invite you to participate and follow up the new publications. The identification of metabolic changes related to cardiovascular diseases using multi-omics approaches is particularly encouraged.

Deadline for manuscript submissions is December 15 2021.

Flyer: Genetics Cardiovascular Metabolism website: Genetics Cardiovascular Metabolism

Working at global leader in artificial activity

X-omics partner, Radboudumc, has 6 vacancies in the area of Artificial Intelligence (AI): 4 full professors and 2 tenure tracks.

Check out all the vacancies

Exposome-Scan project

The Exposome-Scan project, led by Thomas Hankemeier, X-omics core team member, has been granted 3.2 million euros from the NWO Investment Grant Large program.

Exposome-Scan builds on the knowledge gained within X-omics and Exposome-NL. The grant will be used to build a laboratory that will give researchers from all over the Netherlands the opportunity to study the exposome. Such a facility is unique in Europa, and even worldwide there are just a few places where large-scale research into the environment and health takes place.

Read more

X-omics helpdesk - pitch your project and get expert advice

Are you seeking expert advice on experimental design and data integration strategies for a multi-omics approach on your own research project? Register for a pitch your project helpdesk meeting, public or privately!

We received a lot of registrations for the pitch your project sessions in both X-omics workshop series and decided to have these meetings more frequently.

Provide us with your project information via the pitch your project registration and one of the organizers will reach out to you to schedule a meeting. You can choose for a public or private meeting.

Pitch your project

Seeding grant for Neurolipid Atlas project

X-omics member Martin Giera (LUMC) and Rik van der Kant (VUMC) received a Chan Zuckerberg Initiative (CZI) seeding grant of $150,000 for their Neurolipid Atlas project. With this project, they are the first Dutch researchers to join the Neurodegeneration Challenge Network (NDCN), founded by CZI.

This project aims to analyze the lipidome of human iPSC-derived neurons and glia, gene-edited for specific disease variants, and will generate the first map of disease-specific, genotype-specific and cell type-specific changes in the human lipidome associated with neurodegenerative diseases.

More information about this project

If their project will have a successful evaluation after 18 months, they may qualify for a supplementary grant of $1.6 million for the next 4 years.

X-omics YouTube channel

Do you know that X-omics has its own YouTube channel?

All kinds of videos and recordings are already shared here:

In the coming years, more of these type of videos will be uploaded.

The aftermovie of the X-omics festival 2020 will be online soon! Go subscribe to our channel, so you will know when it is online.

X-omics YouTube channel

X-omics @ online events

In October, X-omics will be present at three online conferences, HUPO2020, BioSB2020 and Metabolomics2020.

During these online conferences, X-omics will be presenting its virtual booth in the exhibit halls. Our staff is present to answer any specific questions you have via chats and to videotalk to you!

Not attending any of these events and want to check out our virtual booth? No problem, you can find it here.

On October 28th, Peter-Bram ‘t Hoen (leader of the X-omics data pillar), will present in the parallel topic session “ELIXIR-NL: FAIR resources and training”. He will talk about “Applying the FAIR Data principles to a Rare Disease registry: a case study of the VASCA registry.” Go check out this presentation at 10:15 AM CET.

Also, make sure to check out the poster sessions, a lot of excellent work done by other consortium members will be shown here.

Consortium members Karlien Coene and Purva Kulkarni will be present to show their latest work during the poster sessions:

• 175, “Identification of novel diagnostic biomarkers for classical homocystinuria through untargeted metabolomics/next generation metabolic screening” by Karlien Coene, Radboudumc.
• 228, “Towards precision diagnostics: Untargeted metabolomics for the diagnosis of inborn errors of metabolism in individual patients” by Purva Kulkarni, Radboudumc.

We hope to see you online during these conferences!

Evidence for 28 genetic disorders discovered by combining healthcare and research data

A  collaboration between X-omics partner Radboudumc, GeneDx and the Wellcome Sanger Institute has discovered 28 genes that can be linked to developmental disorders.

Exome-sequence datasets from the three different institutes were combined into a cohort of 31,058 patients in order to have more statistical power. It became the largest statistical study of these mutations to date.

The approach and results of this work have been published in the scientific journal Nature. See the link below for the full article.

X-omics consortium member Christian Gilissen jointly supervised this great work and several other consortium members were involved.

View article

Summary X-omics festival 2020

On September 28th, X-omics organized the second edition of the X-omics festival “the future of X-omics research is now!”.

The event contained a keynote lecture about the 100,000 Genomes Project, lectures from young investigators, lectures with reference to several application areas and technology pitches.

The second X-omics festival was a success and we thank all the speakers, the sponsors and the participants.

An overview of the highlights, key take home messages, presentations and a link to the festival recordings has been compiled and can be found at our festival page.

We hope to see you again during future X-omics events.

Recap festival 2020

UMC Utrecht one of the first GeoMx Premier Access sites

We are excited to announce that our X-omics Genomics core UMC Utrecht has been selected as one of the eight global GeoMx Premier Access Sites. Under this agreement, Edwin Cuppen, Ies Nijman and their team will enable a broader user base to try the Cancer Transcriptome Atlas and evaluate the applicability of GeoMX Digital Spatial Profiler in their research.

NanoString Technologies, a leading provider of life science tools for discovery and translational research, announced the establishment of the GeoMx Premier Access Sites, a global service network that will provide access to the GeoMx Cancer Transcriptome Atlas and future GeoMx commercial assays. The company also announced the availability of the new GeoMx Whole Transcriptome Atlas through the Technology Access Program for the GeoMx Digital Spatial Profiler (DSP). Together these initiatives provide expanded access to next generation sequencing readout on GeoMx DSP.

More information

NWO logoThis research was (partially) funded by NWO, project 184.034.019