Project information

The Netherlands X-omics Initiative (X-omics, pronounce as CROSS-omics) is a National Roadmap Large-Scale Research Infrastructure, partially funded by  NWO with a total budget of 40 million euro. The project started September 2018 and will last for 10 years.

X-omics aims to establish a X-omics research infrastructure across the Netherlands, by combining technologies in the field of genomics, proteomics, metabolomics and data analysis, integration & stewardship. With this infrastructure biomedical problems can be solved using an integrated approach (analysis of samples using the available omics technologies of the infrastructure).

Two major goals are:
1. Advance X-omics technologies far beyond state-of-art,
2. Realize an integrated X-omics infrastructure in the Netherlands.

A central helpdesk has been created to provide access to the research infrastructure and enable researchers to use the newest X-omics technologies in their projects. Via this helpdesk researchers can get into contact with X-omics experts for advice on X-omics approaches.

A proof of principle of the X-omics approach will be provided by starting 3 demonstrator projects on different levels (cellular, individual and population).

During the project, training schools will be set up for new ‘omics’ users and for ‘omics’ practitioners.

To allow communications between the users of the infrastructure a X-omics community will be established. This community will interact via meetings, newsletters and social media.

In our brochure you will find information about:

  • The research infrastructure 
  • X-omics equipment and its services 
  • The helpdesk 
  • Training & events 
  • Our X-omics community 

Access to this infrastructure, its available equipment and services is possible for all researchers by contacting the X-omics helpdesk. 


We will demonstrate the added value of our X-omics approach at 3 levels of biomedical research: the cellular, individual and population level.

Examples of research questions that can be addressed are:


  • How does the metabolism of a single cell change during differentiation?
  • How do cells influence each other’s function?
  • How does a cell respond to cancer drugs or become drug resistant?
  • How do dynamic signaling pathways change in time?


  • What changes molecularly when a person gets sick?
  • What molecular features are shared by rare disease patients?
  • How does the molecular system of a person respond to a biological or pharmaceutical challenge?
  • How similar are phenocopies in health/disease at the molecular level?


  • How can we better understand health and disease?
  • How can we better understand the functional consequences of genetic diversity?
  • How do environmental events affect a population’s molecular system?
  • How can we best translate molecular population data to new screening tools?
NWO logoThis research was (partially) funded by NWO, project 184.034.019